l INDICATIONS AND DOSE

Reduction of absorption of poisons in the gastro-intestinal system 

BY MOUTH 

Neonate: 1 g/kg.  Child 1 month–11 years: 1 g/kg (max. per dose 50 g)  Child 12–17 years: 50 g  Adult: 50 g Active elimination of poisons

 BY MOUTH 

 Neonate: 1 g/kg every 4 hours, dose may be reduced and the frequency increased if not tolerated, reduced dose may compromise efficacy.  Child 1 month–11 years: 1 g/kg every 4 hours (max. per dose 50 g), dose may be reduced and the frequency increased if not tolerated, reduced dose may compromise efficacy  Child 12–17 years: Initially 50 g, then 50 g every 4 hours, reduced if not tolerated to 25 g every 2 hours, alternatively 12.5 g every 1 hour, reduced dose may compromise efficacy  Adult: Initially 50 g, then 50 g every 4 hours, reduced if not tolerated to 25 g every 2 hours, alternatively 12.5 g every 1 hour, reduced dose may compromise efficacy Accelerated elimination of teriflunomide ? BY MOUTH USING GRANULES ? Adult: 50 g every 12 hours for 11 days Accelerated elimination of leflunomide (washout procedure)

 BY MOUTH USING GRANULES 

Adult: 50 g 4 times a day for 11 day

 l UNLICENSED USE

 In adults Activated charcoal doses in BNF may differ from those in product literature.

l CAUTIONS

Comatose patient (risk of aspiration—ensure airway is protected). drowsy patient (risk of aspiration— ensure airway protected).reduced gastrointestinal motility (risk of obstruction)

l SIDE-EFFECTS

Bezoar. constipation . diarrhoea . gastrointestinal disorders

l DIRECTIONS FOR ADMINISTRATION

Suspension or reconstituted powder may be mixed with soft drinks (e.g. caffeine-free diet cola) or fruit juices to mask the taste.